Muddled water

When I was in BJ with my mom in August for her hysterectomy (just double-checked the spelling of the word and was surprised to see I got it right. Not happy with my new knowledge though.), I told my properly scared and anxious brother in Hong Kong to come, thinking that it’d give my mom very good comfort and support as well as earn a bit more together-time–who knows how much have we got. It’d also be a good comfort for my brother I thought, and I told him that standing in the muddled water is, actually, less scary than looking at it from the shore.

Just now I realize how wise I was saying that — as I am now in Hong Kong and my mom is in BJ, I can’t possibly express how restless I feel. (No, modesty is not my virtue….) Long story short mom relocated to BJ for new work as well as a new relationship –haven’t seen her being THAT happy since I lost my dad, so I am really happy for her. Her partner, a renown traditional Chinese medical doctor, is now taking care of her. Typing this line makes me feel like I am over-demanding–this personal, 24/7 professional and personal medical care ‘services’ are unavailable to most patients. Mr. Doctor is in his 80s and looks like a 60s, with a strength stronger and a mind sharper than mine. (Confessional Mode turned-on) I threw a pretty bad tantrum the other day to Mr. Doctor and I am actually feeling a little sorry. I was uncontrollably angry when he said I, as an illiterate in medicine, have doubts over the professional decisions of my mom’s doctor when I was asking if there’s any index for reference for the effectiveness of the chemotherapy; my quest for the possibility of a chemo drug with less side-effect was regarded as ‘giving trouble to the current plan’.

But I have to say that the ‘current plan’, designed by my mom’s current doctor, is, according to the doctor herself, not very useful and there’s nothing more effective on earth for the moment due to the aggressiveness of the sarcoma and the rarity of the case, which provides insufficient data for research. She said many of the patients do not live more than a year after the operation.

Not being able to make a scientific/medical decision good for my mom, I choose the option that can make her happy –which I believe will certainly benefit her health.

And bear the consequence of the decision. I think this is the lesson of growing-up.

On rarity

There’s relatively few medical research on ULMS, there’s basically no view of this blog. Though the thought of not many people on earth need to look up ULMS frantically like I do makes me happy, I am, deep-down, annoyed, if not offended, by the RARITY of ULMS as many professional and popular information claims. Has it been so rare why the heck does it happen on my mom? Why haven’t other equally rare chances, like winning the lottery, bestowed on me?

Let me look up the amount of the first prize for the next lottery, and buy it 🙂

Liposome 微脂體, and on online non-professional medical research

Have come across a (no-longer) new chemo drug called liposome, though some research suggests that it’s not too helpful for ULMS:

Phase II evaluation of liposomal doxorubicin (Doxil) in recurrent or advanced leiomyosarcoma of the uterus: a Gynecologic Oncology Group study

‘Conclusion: The dose and schedule of liposomal doxorubicin employed in this trial showed no advantage over historical results with doxorubicin in the treatment of uterine leiomyosarcoma.’

微脂體簡介

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William ‘Bill’ Peeples has now become my new hero. Long story short after his wife, Vera, was given the diagnosis of an aggressive sarcoma at an advanced stage and told nothing can be done by doctors, Bill carried out his online research and saved his wife. Doing similar things right now for my mom, I truly admire Bill’s dedication, determination and the enormous capacity of concentration and clarity. I have yet found my way I’d say, despite the fact that having been in the academia all my life engaged in multidisciplinary researches. The discourse of medical science is like a language from the outer space, and until now I still haven’t figured out how ULMS occurs, metastasizes and kills–let alone how to kill it. I am constantly distracted by different information and taken into searches into myriad issues. I hope these are just the pieces of a puzzle and they would come into a picture eventually.

Curcumin, curcumin!! 薑黃有奇效

I Will get my mom this. Products with this substance is also recommended by this blogger (link below)–who’s been clean for 5+ years and has ‘graduated’ from the condition!!!

有研究指薑黃(curcumin)有效抑制ULMS。其實有個博客都強列推介含有這種物制的產品,她還是個已康復的病友:

Jeannie Ross’s blog

還有: Curcumin disrupts uterine leiomyosarcoma cells through AKT-mTOR pathway inhibition

BPC Cancer Protocol

Int J Clin Oncol. 2014 Apr;19(2):354-63. doi: 10.1007/s10147-013-0563-4. Epub  2013 May 11.
Curcumin targets the AKT-mTOR pathway for uterine leiomyosarcoma tumor growth suppression.
1Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Abstract

BACKGROUND:
Uterine leiomyosarcomas generally do not respond well to standard chemotherapy. We previously demonstrated that curcumin, the active ingredient derived from the herb Curcuma longa, inhibits uterine leiomyosarcoma cells in vitro via the inhibition of the AKT-mammalian target of rapamycin (mTOR) pathway. As a preclinical investigation, we performed an in vivo study using female nude mice to confirm the therapeutic potential of curcumin against uterine leiomyosarcoma.
METHODS:
Human leiomyosarcoma cells, SK-UT-1, were inoculated in female nude mice to establish subcutaneous tumors. Either vehicle control or 250 mg/kg curcumin was administered intraperitoneally every day for 14 consecutive days, and the mice were then killed. The tumors were measured every 2-3 days. The tumors…

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